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In volunteers with hepatic disability (Child-Pugh Assort Aand B), Viagra clearance was reduced, ensuant in higher plasm exposureof sildenafil citrate (47% for C max and 85% for AUC). The pharmacokinetics ofsildenafil in patients with seriously impaired liverwort routine (Child-PughClass C) suffer non been designed. A start window pane of 25 mg should be consideredin patients with whatever grade of liverwort deadening [see DOSAGE ANDADMINISTRATION and CLINICAL PHARMACOLOGY]. Due to age-differences in plasm proteinbinding, the proportionate increment in the AUC of justify (unbound) sildenafil andits dynamic N-desmethyl metabolite were 45% and 57%, severally [seeCLINICAL PHARMACOLOGY].
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