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Although ICOS scientists were not examination combine IC351 for treating ED, they recognised its potential drop usefulness for treating that perturb. Soon, in 1994, ICOS accepted a patent of invention for deepen IC351 (structurally different sildenafil and vardenafil), and Stage 1 clinical trials began in 1995. In 1997, the Stage 2 clinical studies were initiated for males experiencing ED, then progressed to the Phase 3 trials that supported the drug's Food and Drug Administration blessing.